(+)-Cloprostenol methyl ester
(+)-Cloprostenol is a synthetic analog of prostaglandin F2? (PGF2?). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. It is 200 times and 100 times more potent than PGF2? in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2?.{1182} Cloprostenol is also used in veterinary medicine as a luteolytic agent for the induction of estrus and the treatment of reproductive disorders in cattle, swine, and horses. (+)-Cloprostenol methyl ester is a more lipid soluble form of cloprostenol, which may be more amenable for certain formulations.
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