Recombinant Human Insulin-like Growth Factor I
IGF-I (Insulin-like Growth Factor I), is a secreted mitogenic polypeptide and member of the insulin gene family, produced primarily by the liver, which effects a wide range of cells and plays a key role in cell proliferation and growth, inhibition of apoptosis, and is linked with tumour cell growth.IGF-I signals through binding to the type 1 insulin-like growth factor receptor (IGF-1R) and also to the insulin receptor (IR), resulting in the activation of the AKT signalling pathway. IGF-I production is stimulated by growth hormone (GH). and can be hindered by GH insensitivity, deficiency in GH receptors or a malfunction in the post GH receptor signalling pathway.
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Recombinant Human Insulin-like Growth Factor I
PHP177
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Recombinant Human Insulin-like Growth Factor I
PHP177
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